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Adult & Pediatric Allergy & Immunology Cheat Sheet 2026: One-Page Review of Must-Know Facts

TL;DR
  • Basic science is 30% of the PAAI exam - the single largest content area by far.
  • 250 questions across four 90-minute sections; total seated time is 6 hours 50 minutes with breaks.
  • Passing requires a scaled score of 500 on a 200-800 scale, not a raw percentage cutoff.
  • Initial exam costs $1,700; a retake is $1,400; cancel 15+ days out to recover most of your fee.

Exam Snapshot: Format, Timing, Fees

The Adult & Pediatric Allergy & Immunology subspecialty exam (PAAI) is administered by the American Osteopathic Conjoint Examination Committee on Pediatric and Adult Allergy and Immunology under the AOA. Before you touch a single practice question, memorize this operational skeleton - it shapes how you pace your prep and your test day.

  • Question count: 250 multiple-choice items
  • Sections: four sections of 90 minutes each, containing 63, 62, 63, and 62 questions respectively
  • Breaks: 10 minutes, 30 minutes, 10 minutes - scheduled between sections
  • Total appointment length: 6 hours of answering plus 50 minutes of breaks = 6 hours 50 minutes
  • Delivery: remote-proctored through MonitorEDU on the PARADIGM examination platform
  • Initial exam fee: $1,700; retake fee: $1,400
  • Cancellation policy: written cancellation at least 15 full days before the exam qualifies for a refund minus a $300 processing fee

For a fuller walkthrough of how these pieces fit together, see the exam dates and scheduling guide and the certification cost breakdown.

Why the schedule matters: Four 90-minute blocks with only three breaks means you need stamina training, not just content review. Practice sitting through 90-minute question blocks without a pause during your prep so exam day pacing feels routine.

Domain Breakdown at a Glance

The initial-examination blueprint has eight content areas that total 100%. This is the blueprint you should study against - the separate OCC blueprint used for longitudinal assessment is different and not the focus of this cheat sheet.

DomainWeight
Basic science30%
Primary and secondary immunodeficiencies10%
GI disorders10%
Autoimmunity and other immunological disorders3%
Pulmonary diseases13%
Hypersensitivity reactions and mast cell disorders11%
Allergic and non-allergic upper respiratory tract diseases13%
Skin disorders10%

Notice that four domains - pulmonary diseases, hypersensitivity/mast cell disorders, upper respiratory tract diseases, and skin disorders - each sit in the 10-13% range. Collectively they outweigh basic science, so don't let the single largest domain crowd out balanced review of these four. A domain-by-domain walkthrough with sub-topics lives in the complete exam domains guide.

Basic Science: The 30% You Cannot Skip

Domain 1: Basic Science (30%)

This is the largest single content area on the PAAI blueprint, and it underpins how questions in every other domain are written. Expect items testing mechanism-level understanding rather than pure recall.

  • Innate and adaptive immune cell function, signaling pathways, and cytokine networks
  • Immunoglobulin structure, class switching, and complement cascade mechanics
  • Genetics and molecular basis of immune-mediated disease
  • Laboratory interpretation fundamentals that connect basic mechanisms to clinical values

Because basic science carries nearly a third of the exam's weight, it deserves the first and most repeated study pass. Many candidates under-invest here because it feels "textbook" rather than clinical - that's a mistake given the scoring math. Treat it as the foundation domain in your first-attempt study guide plan, not an afterthought.

Clinical Domains: Quick-Reference Table

The remaining seven domains are clinically oriented. Use this table as a rapid recall check during your final review pass - if you can't state two or three high-yield topics per row from memory, that domain needs another pass.

DomainCore Focus Areas to Master
Primary and secondary immunodeficienciesAntibody deficiencies, combined immunodeficiencies, secondary causes, diagnostic workup sequencing
GI disordersFood protein-induced conditions, eosinophilic GI disease, immune-mediated enteropathies
Autoimmunity and other immunological disordersSystemic autoimmune presentations relevant to allergy/immunology practice
Pulmonary diseasesAsthma phenotypes, hypersensitivity pneumonitis, pulmonary manifestations of immune disease
Hypersensitivity reactions and mast cell disordersDrug hypersensitivity, anaphylaxis mechanisms, mastocytosis and mast cell activation
Allergic and non-allergic upper respiratory tract diseasesRhinitis subtypes, sinusitis, upper airway allergic disease management
Skin disordersUrticaria, atopic dermatitis, cutaneous manifestations of systemic allergic disease

Key Takeaway

Autoimmunity is only 3% of the blueprint - don't let it consume disproportionate study hours. Redirect that time toward basic science and the three domains weighted at 13% and 11%.

Eligibility and Registration Mechanics

Before you can register, confirm you meet the underlying eligibility structure:

  • AOBIM or AOBP primary certification
  • An active, unrestricted medical license
  • Professional and ethical standing consistent with board requirements
  • Completion and verification of qualifying allergy/immunology fellowship training

Senior fellows get a limited exception: you may sit for the exam after completing at least 80% of required clinical rotations, but the certification itself is not finalized until your training completion is fully verified. If you're mapping out timing between fellowship graduation and exam eligibility, the requirements and eligibility guide covers this in more depth, and the main certification overview is a good starting reference if you're still confirming pathway details.

Refund mechanics: Written cancellation submitted at least 15 full days before your scheduled exam date qualifies for a refund of your fee minus a $300 processing fee. Miss that window and you likely forfeit the full amount - build your fellowship and licensure paperwork timeline around this deadline.

Remote Test-Day Logistics

Because delivery is remote-proctored through MonitorEDU on the PARADIGM platform, your test-day checklist looks different from a testing-center exam:

  • A suitable computer and a smartphone with a working camera
  • Valid identification matching your registration
  • A private, quiet test space free of prohibited materials
  • Electronic lab values, an on-screen calculator, and a digital scratchpad are all provided within the platform - you don't need to bring your own

Run a full technical check well before your appointment window; remote proctoring failures are avoidable but only if you test your setup in advance. For a broader discussion of what makes this exam demanding beyond logistics, read how hard the exam actually is.

Scoring, Retakes, and Certificate Terms

Passing is determined by a scaled score of 500 on a 200-800 scale - this is not a raw percentage-correct cutoff, so don't try to reverse-engineer a "70% equivalent." The scaling accounts for item difficulty across the form you receive. For a deeper explanation of what that scaled score actually represents, see the passing score breakdown.

If a retake is necessary, the fee drops to $1,400 versus the $1,700 initial fee. Certificate terms also matter for long-range planning:

  • Certificates issued before 2025 carry a ten-year term
  • The 2025 cohort receives a shorter two-year term

This distinction affects when you'll first engage with maintenance requirements, so confirm which cohort you fall into rather than assuming the standard ten-year cycle applies.

Maintenance and OCC Basics

Once certified, ongoing maintenance (Osteopathic Continuous Certification, OCC) runs on its own separate track from the initial exam blueprint discussed above. Key mechanics to know:

  • 16 untimed, open-resource PAAI questions annually
  • A 70% annual passing criterion on that component
  • A $250 annual assessment fee
  • The 2026 assessment cycle is delivered through the AOA Learning Portal
  • New diplomates begin OCC participation after one full calendar year of certification - the 2025 cohort starts in 2027
  • Maintenance also requires active licensure, primary-board CME compliance (no separate conjoint-subspecialty CME quota), and one quality-improvement activity every ten years

Because OCC uses a different content structure than the initial exam, don't conflate the two blueprints while studying for your first attempt - focus your PAAI prep entirely on the eight-domain initial exam breakdown above.

Final-Week Review Sequencing

With basic science carrying 30% of the weight, your final review weeks should be sequenced deliberately rather than reviewed alphabetically or randomly.

Week 1

Basic Science Deep Pass

  • Immune mechanisms, complement, genetics - the highest-weighted domain first
Week 2

The Mid-Weight Trio

  • Pulmonary diseases (13%), upper respiratory tract diseases (13%), hypersensitivity/mast cell disorders (11%)
Week 3

Even-Weight Domains

  • Immunodeficiencies (10%), GI disorders (10%), skin disorders (10%)
Week 4

Low-Weight Domain + Full Timed Blocks

  • Autoimmunity (3%) plus full 90-minute practice blocks to build stamina for the 6-hour-50-minute exam day

This weighting-first sequencing (not a generic spaced-repetition template) is the fastest way to align study hours with the actual scoring math. For a complete week-by-week strategy built around this same logic, see the full study guide.

Who this certification serves: Diplomates typically practice in allergy/immunology clinics, academic medical centers, and hospital systems where AOBIM or AOBP primary certification plus subspecialty credentialing is required or preferred. If you're weighing career impact, compare the earnings analysis against the total cost of certification before committing to a testing date.

Want to gauge your baseline before locking in a date? Run a timed practice session on the main practice test platform to see how your pacing and accuracy hold up across all four 90-minute sections. You can also revisit the practice test homepage periodically as you move through each study week to track improvement across domains.

FAQ

How many questions are on the Adult & Pediatric Allergy & Immunology exam?

250 multiple-choice questions total, split into four sections of 63, 62, 63, and 62 questions, each timed at 90 minutes.

What score do I need to pass?

A scaled score of 500 on a 200-800 scale. It is not based on a raw percentage-correct threshold. See the passing score guide for more detail.

Which domain should I prioritize first?

Basic science, at 30% of the blueprint, is the single largest content area and should anchor your earliest and most thorough review pass.

Can I get a refund if I need to cancel?

Yes, if you submit written cancellation at least 15 full days before your exam date. A $300 processing fee is deducted from the refund.

Is the exam taken at a physical test center?

No. It is remote-proctored through MonitorEDU on the PARADIGM platform, requiring a computer, smartphone camera, ID, and a private testing space.

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